Evidence-based cost-benefit analysis of Vitamin D.
Vitamin D supplementation has been shown to improve glycemic control and metabolic parameters in patients with diabetes. It may lower levels of glycosylated hemoglobin (HbA1c), improve insulin sensitivity (HOMA-IR), and reduce inflammatory markers such as C-reactive protein. The proposed mechanisms include the modulation of calcium metabolism and insulin secretion, as well as anti-inflammatory effects.
Individuals with diabetes or prediabetes, particularly those with low vitamin D levels, may benefit most from supplementation. It may also be useful for those at risk of metabolic syndrome or cardiovascular diseases.
Vitamin D supplementation is generally safe when taken within recommended doses, but excessive intake can lead to toxicity. It is important to monitor blood levels of vitamin D and consult with a healthcare provider, especially for individuals on medications that may interact with vitamin D metabolism.
Compare other supplements by cost and evidence
Educational and research purposes only. Always consult a healthcare professional before starting any supplement regimen. ROI is modelled at $100,000 per quality-adjusted life year; see the methodology.