Vitamin B1: Cost, Evidence & ROI

Evidence-based cost-benefit analysis of Vitamin B1.

Monthly cost

$26

QALY gain per year

+0.017

Return on investment

+64.4x

Evidence level

Medium (moderate clinical evidence)

What the research shows

Vitamin B1 (Thiamine) supplementation has been shown to potentially alleviate anxiety and stress while improving sleep quality, as evidenced by a randomized, double-blind, placebo-controlled trial. The proposed mechanisms include its role in neurotransmitter synthesis and energy metabolism, which may contribute to mood regulation and neuroprotection.

Reported benefits

• May reduce symptoms of anxiety as indicated by improvements in Self-Rating Anxiety Scale scores.
• Potentially lowers perceived stress levels, as measured by the Perceived Stress Scale.
• Improves sleep quality, supported by enhancements in the Pittsburgh Sleep Quality Index.
• Supports overall mood regulation and neuroprotection through its role in energy metabolism.

Who it is for

Individuals experiencing anxiety, high levels of stress, or sleep disturbances may benefit most from Vitamin B1 supplementation. This includes those with lifestyle-related stressors, such as students, professionals in high-pressure jobs, or individuals with sleep issues.

Considerations

Vitamin B1 is generally considered safe when taken at recommended doses. However, individuals with specific medical conditions or those taking certain medications should consult a healthcare provider before starting supplementation. Potential interactions with other B vitamins should also be considered, as they often work synergistically.

Compare other supplements by cost and evidence

Educational and research purposes only. Always consult a healthcare professional before starting any supplement regimen. ROI is modelled at $100,000 per quality-adjusted life year; see the methodology.